- Product Details
Keywords
- cas 956697-53-3
- Erismodegib
- LDE225
Quick Details
- ProName: Sonidegib
- CasNo: 956697-53-3
- Molecular Formula: C26H26F3N3O3
- Appearance: Solid Powder
- Application: inhibitor
- DeliveryTime: 7 days
- ProductionCapacity: 1 Kilogram/Month
- Purity: 98%
- LimitNum: 1 Gram
Superiority
BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds. #
Details
Sonidegib, also known as, erismodegib (LDE225, NVP-LDE225) is an orally bioavailable small-molecule Smoothened (Smo) antagonist with potential antineoplastic activity. Erismodegib selectively binds to the Hedgehog (Hh)-ligand cell surface receptor Smo, which may result in the suppression of the Hh signaling pathway and, so, the inhibition of tumor cells in which this pathway is abnormally activated. The Hh signaling pathway plays an important role in cellular growth, differentiation and repair. Inappropriate activation of Hh pathway signaling and uncontrolled cellular proliferation, as is observed in a variety of cancers, may be associated with mutations in the Hh-ligand cell surface receptor Smo.