CAY10575 CAS NO.916985-21-2

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NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival. NF-κB is activated upon degradation of IκB following IKK-α and IKK-β phosphorylation. IKK-ε, a homolog of IKK-α and IKK-β, can also activate NF-κB. CAY10512 is an analog of Resveratrol that is 100-fold more potent with IC?? of 150 nM at inhibiting NF-κB activation by TNF-α. It does not exhibit antioxidant activity in either the ferric reducing/antioxidant power (FRAP) or total radical antioxidant parameter (TRAP) assays.