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BMS 688521 CAS NO.893397-44-9
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Keywords
- 6-[(5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4,4]non-7-yl]-3-pyridinecarboxylic acid
- BMS-688521
Quick Details
- ProName: BMS 688521
- CasNo: 893397-44-9
- Molecular Formula: C26H19Cl2N5O4
- Application: For research use only.
- Purity: ≥98%
- LimitNum: 0
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Details
BMS 688521 is a small molecule antagonist of leukocyte function associated antigen-1 (LFA-1). It has provided proof-of-concept for LFA-1 as an immunological target. BMS 688521 is a potent inhibitor of the LFA-1/ICAM-1 interaction (IC50 values are 2.5 and 78 nM in HUVEC adhesion and mouse specific adhesion assays respectively), which inhibits eosinophil accumulation in the lungs in a mouse allergic eosinophilic lung inflammation model.
