United States
Premiumsupplier
MMAF-OMe CAS NO.863971-12-4
- Min.Order: 0 Metric Ton
- Payment Terms:
- Product Details
Keywords
- 863971-12-4
- cas 863971-12-4
- ADCs Cytotoxin
Quick Details
- ProName: MMAF-OMe
- CasNo: 863971-12-4
- Molecular Formula: C40H67N5O8
- Application: Research use
- PackAge: according to the clients requirement
- ProductionCapacity: Metric Ton/Day
- Purity: ≥ 97%
- Transportation: by sea or by air
- LimitNum: 0 Metric Ton
Superiority
MMAF-Ome is a methoxyl analogue of MMAF, used in antibody-drug conjugates (ADCs) as the antimitotic agent part. The methoxyl works as the reaction group. MMAF is a potent auristatin-derived antineoplastic agent, working by inhibition of tubulin polymerization. It exhibited cytotoxicity in Karpas 299, H3396, 786-O and Caki-1 cells with IC50 values of 119nM, 105nM, 257nM and 200nM after 96-hour treatment. #
Details
MMAF-Ome is a methoxyl analogue of MMAF, used in antibody-drug conjugates (ADCs) as the antimitotic agent part. The methoxyl works as the reaction group. MMAF is a potent auristatin-derived antineoplastic agent, working by inhibition of tubulin polymerization. It exhibited cytotoxicity in Karpas 299, H3396, 786-O and Caki-1 cells with IC50 values of 119nM, 105nM, 257nM and 200nM after 96-hour treatment. #