4-methoxy-5-(3-morpholinopropoxy)-2-nitrobenzamide CAS NO.861453-16-9

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4-methoxy-5-(3-morpholinopropoxy)-2-nitrobenzamide is an impurity of Gefitinib. Gefitinib is an antineoplastic drug. Gefitinib effectively inhibits all tyrosine phosphorylation sites on EGFR in both the high and low EGFR-expressing cell lines including NR6, NR6M and NR6W cell lines. The phosphorylation sites Tyr1173 and Tyr992 are less sensitive requiring higher concentrations of Gefitinib for inhibition.