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DL-threo-PDMP hydrochloride CAS NO.80938-69-8
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Keywords
- DL-PDMP
- D,l-Threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol HCl
Quick Details
- ProName: DL-threo-PDMP hydrochloride
- CasNo: 80938-69-8
- Molecular Formula: C23H38N2O3·HCl
- Appearance: Crystalline Solid
- Application: For research use only.
- Purity: ≥98%
- LimitNum: 0
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Details
DL-threo PDMP is a mixture of ceramide analogs that contains two of the four possible stereoisomers of PDMP: D-threo (1R,2R) and L-threo (1S,2S) PDMP. DL-threo-PDMP inhibits glucosylceramide synthase by 33 and 48% in MDCK cell homogenates when used at concentrations of 5 and 10 μM. It reduces the synthesis of glucosylceramide, increases cellular ceramide, and induces cell cycle arrest in vitro.
