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Home > Products >  ZJ 43

ZJ 43 CAS NO.723331-20-2

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Keywords

  • ZJ 43
  • ZJ43

Quick Details

  • ProName: ZJ 43
  • CasNo: 723331-20-2
  • Molecular Formula: C12H20N2O7
  • Application: For research use only.
  • Purity: 95%
  • LimitNum: 0

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Details

ZJ 43 is a potent inhibitor of glutamate carboxypeptidase II and III (GCP II and III/NAAG peptidase/NAALADase) (Ki = 0.8 and 23 nM, respectively). It inhibits the hydrolysis of NAAG (IC50 = 2.4 nM) and decreases the deleterious effects of excessive extracellular glutamate. ZJ 43 has been shown to reduce neuronal degeneration in a rat model of traumatic brain injury (TBI) and reduce locomotor activity in the PCP-model of schizophrenia.

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