Quick Details
- ProName: ZJ 43
- CasNo: 723331-20-2
- Molecular Formula: C12H20N2O7
- Application: For research use only.
- Purity: 95%
- LimitNum: 0
Superiority
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Details
ZJ 43 is a potent inhibitor of glutamate carboxypeptidase II and III (GCP II and III/NAAG peptidase/NAALADase) (Ki = 0.8 and 23 nM, respectively). It inhibits the hydrolysis of NAAG (IC50 = 2.4 nM) and decreases the deleterious effects of excessive extracellular glutamate. ZJ 43 has been shown to reduce neuronal degeneration in a rat model of traumatic brain injury (TBI) and reduce locomotor activity in the PCP-model of schizophrenia.