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Ilimaquinone CAS NO.71678-03-0
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Keywords
- ilimaquinone
- 71678-03-0
Quick Details
- ProName: Ilimaquinone
- CasNo: 71678-03-0
- Molecular Formula: C22H30O4
- Appearance: Solid Powder
- Application: For research use only.
- Purity: ≥98%
- Storage: Powder:
-20°C: 3 years
4°C: 2 ... - LimitNum: 0
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Details
Ilimaquinone is a marine sponge metabolite with antimicrobial, anti-HIV, anti-mitotic, and anti-inflammatory properties. Ilimaquinone significantly enhanced TRAIL-induced apoptosis in HCT 116 cells and sensitized colon cancer cells to TRAIL-induced apoptosis through increased caspase-8, -3 activation, PARP cleavage, and DNA damage. Ilimaquinone also reduced the cell survival proteins Bcl2 and Bcl-xL, while strongly up-regulating death receptor (DR) 4 and DR5 expression.
