BX795 CAS NO.702675-74-9

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BX795 is a potent and selective inhibitor of PDK1, IKKε and TBK1, which regulates the production of Type 1 interferons during bacterial and viral infection. BX795 blocks the phosphorylation, nuclear translocation, and transcriptional activity of interferon regulatory factor 3 and the production of interferon-β in macrophages stimulated with poly(I:C) or lipopolysaccharide (LPS). BX795 also inhibits ERK8, MAPK-interacting kinase 2, Aurora B, Aurora C, MAP/microtubule affinity-regulating kinases 1-4, TNF receptor associated factor-associated NF-κB activator-binding kinase 1.