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BW 755C CAS NO.66000-40-6
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Keywords
- BW755C
- BW-755C
Quick Details
- ProName: BW 755C
- CasNo: 66000-40-6
- Molecular Formula: C10H10F3N3
- Appearance: Crystalline Solid
- Application: Anti-Inflammatory Agents, Non-Steroida...
- Purity: ≥95%
- Storage: Store at -20°C
- LimitNum: 0
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Constitutive cyclooxygenase (COX-1) is present in cells under physiological conditions, whereas COX-2 is induced by some cytokines, mitogens, and endotoxin in pathological conditions, such as inflammation. Since 5-lipoxygenase (5-LO) oxidizes arachidonic acid to 5-hydroperoxyeicosatetraenoic acid. BW 755C is a dual inhibitor of 5-lipoxygenase (5-LO) and cyclooxygenase (COX) pathways. It inhibits 5-LO with IC50s of 0.75 μM, COX-1 with IC50s of 0.65 μg/ml, and COX-2 with IC50s of 1.2 μg/ml. BW 755C may also inhibit other LO pathways in vivo.
