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CDK4 Inhibitor CAS NO.546102-60-7
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Keywords
- 2-Bromo-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione
Quick Details
- ProName: CDK4 Inhibitor
- CasNo: 546102-60-7
- Molecular Formula: C20H10BrN3O2
- Appearance: Crystalline Solid
- Application: For research use only.
- Purity: ≥90%
- LimitNum: 0
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Details
Cdk4 inhibitor is a cell-permeable, asymmetrical indolocarbazole that exhibits antiproliferative activity by blocking cyclin D1/Cdk4 with an IC50 of 0.8 μM. It also inhibits the activity of other Cdk's only at much higher concentrations (IC50 = 520 nM and 2.1 μM for Cdk2/E and Cdk1/B, respectively). Cdk4 inhibitor can inhibit tumor cells growth in HCT-116 and NCI-H460 cells (IC50 < 3.0 μM).
