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5-(Hydroxymethyl)-2'-deoxyuridine CAS NO.5116-24-5
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- Product Details
Keywords
- a-hydroxythymidine
- 5-Hydroxymethyl-2'-deoxyuridine
Quick Details
- ProName: 5-(Hydroxymethyl)-2'-deoxyuridine
- CasNo: 5116-24-5
- Molecular Formula: C10H14N2O6
- Appearance: White to Off-white Solid
- Application: Antineoplastic Agents
- PackAge: 1 g
- Purity: ≥95%
- Storage: Store at -20°C under inert atmosphere
- LimitNum: 0
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Details
5-(Hydroxymethyl)-2'-deoxyuridine is a nucleoside analog with anticancer and antiviral activities. It inhibits the replication of murine S180 lung carcinoma cells and Ehrlich ascites mammary carcinoma cells (ED50s = 8.5 and 4 μM, respectively) and multiple human leukemia cell lines (IC50s = 1.7-5.8 μM). 5-(Hydroxymethyl)-2'-deoxyuridine acts synergistically with 5-fluorouracil (5-FU) against HT-29, HCT116, PANC-1, and EKVX cancer cells with no effect on WI38 embryonic lung fibroblasts.
