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BRD32048 CAS NO.433694-46-3
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Keywords
- BRD-32048
- BRD 32048
Quick Details
- ProName: BRD32048
- CasNo: 433694-46-3
- Molecular Formula: C16H22N6O
- Appearance: Crystalline Solid
- Application: For research use only.
- Purity: ≥98%
- LimitNum: 0
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Details
The ETV1 transcription factor is phosphorylated downstream of MAPK signaling and is acetylated at lysines 33 and 116 by the histone acetyltransferase p300. BRD32048 is an inhibitor of the ETV1 transcription factor oncoprotein. BRD32048 binds ETV1 directly, modulating both ETV1-mediated transcriptional activity and invasion of ETV1-driven cancer cells. BRD32048 is a substituted [1,3,5]triazine derivative that inhibits ETV1 transcriptional activity by binding to ETV1 with KD of 17.1 μM, which reduces p300-dependent acetylation and stability of ETV1.
