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Ac-Nle-Pro-Nle-Asp-AMC CAS NO.355140-49-7
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- Product Details
Keywords
- Ac-Nle-Pro-Nle-Asp-7-amido-4-Methylcoumarin
- Ac-nLPnLD-AMC
Quick Details
- ProName: Ac-Nle-Pro-Nle-Asp-AMC
- CasNo: 355140-49-7
- Molecular Formula: C33H45N5O9
- Appearance: White Lyophilized Powder
- Application: For research use only.
- Purity: ≥98%
- Storage: Store at -20°C
- LimitNum: 0
Superiority
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Details
Ac-Nle-Pro-Nle-Asp-AMC is a substrate for proteasomes. It can be cleaved by the caspase-like site of proteasome, also known as postglutamyl peptide hydrolase (PGPH). AMC (7-amino-4-methylcoumarin) is released and produces the fluorescence utilized to quantify the caspase-like site activity. Ac-Nle-Pro-Nle-Asp-AMC also inhibits the chymotrypsin-like activity of the proteasome allosterically when bound to the caspase-like site.
