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KRIBB11 CAS NO.342639-96-7
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Keywords
- N2-(1H-indazole-5-yl)-N6-methyl-3-nitropyridine-2,6-diamine
- KRIBB11
Quick Details
- ProName: KRIBB11
- CasNo: 342639-96-7
- Molecular Formula: C13H12N6O2
- Appearance: Solid powder
- Application: For research use only.
- Purity: 95%
- Storage: Store in a cool and dry place (or refe...
- LimitNum: 0
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Details
KRIBB11 is a heat shock factor (HSF) inhibitor (IC50 = 1.2 μM). KRIBB11 inhibits HSP70 synthesis through inhibition of heat shock factor 1 function by impairing the recruitment of positive transcription elongation factor b to the hsp70 promoter. In vivo, administration of KRIBB11 decreases tumor growth in a mouse HCT116 xenograft model.
