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RH1 CAS NO.221635-42-3
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Keywords
- RH 1
- RH-1
Quick Details
- ProName: RH1
- CasNo: 221635-42-3
- Molecular Formula: C12H14N2O3
- Application: For research use only.
- Purity: 95%
- LimitNum: 0
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Details
RH1 is a new bioreductive agent that is an excellent substrate for the two-electron reducing enzyme, NAD(P)H quinone oxidoreductase 1 (NQO1). In phase trials, RH1 was well tolerated with predictable and manageable toxicity. The MTD of 1430 μg/m(2)/day is the dose recommended for phase II trials. The biomarkers of DNA cross linking, DTD activity and NQO1 status have been validated and clinically developed.
