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RO1138452 CAS NO.221529-58-4
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Keywords
- RO-1138452
- RO1138452
Quick Details
- ProName: RO1138452
- CasNo: 221529-58-4
- Molecular Formula: C19H23N3O
- Application: For research use only.
- PackAge: 50 mg
- Purity: 95%
- LimitNum: 0
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Details
RO1138452 is one of the most potent high-affinity ligands and functional antagonists for the human IP (prostacyclin) receptor. It exhibits no affinity at other prostanoid receptors (EP1-4, FP and TP) in a radioligand binding assay. RO1138452 antagonizes the carbaprostacyclin-induced activation of human neuroblastoma adenylate cyclase, blocking cyclic AMP accumulation in a dose-dependent manner.
