- Product Details
Keywords
- 2100284-59-9
- cas 2100284-59-9
- AZ-3451
Quick Details
- ProName: AZ 3451
- CasNo: 2100284-59-9
- Molecular Formula: C30H27BrN4O3
- Appearance: Solid Powder
- Application: research use
- DeliveryTime: 7 days
- ProductionCapacity: 1 Kilogram/Month
- Purity: ≥98%
- LimitNum: 1 Gram
Superiority
BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds. #
Details
AZ3451 is a potent and selective allosteric antagonist of protease-activated receptor 2 (PAR2) with IC50 of 23 nM. AZ3451 was found to bind to a remote allosteric site outside the helical bundle that is different from the site previously found on PAR1. The interaction of AZ3451 with PAR2 is predominately hydrophobic in nature. AZ3451 binds to a remote allosteric site outside the helical bundle, which prevents structural rearrangements required for receptor activation and signaling.