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Semaxinib CAS NO.204005-46-9
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Keywords
- SU5416
- SU-5416
Quick Details
- ProName: Semaxinib
- CasNo: 204005-46-9
- Molecular Formula: C15H14N2O
- Appearance: Yellow to Orange Solid Powder
- Application: Angiogenesis Inhibitors
- PackAge: 100 mg
- Purity: 98%
- LimitNum: 0
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Details
Semaxinib is a quinolone derivative with potential antineoplastic activity. Semaxinib reversibly inhibits ATP binding to the tyrosine kinase domain of vascular endothelial growth factor receptor 2 (VEGFR2), which may inhibit VEGF-stimulated endothelial cell migration and proliferation and reduce the tumor microvasculature. This agent also inhibits the phosphorylation of the stem cell factor receptor tyrosine kinase c-kit, often expressed in acute myelogenous leukemia cells.
