United States
Premiumsupplier
TAS4464 CAS NO.1848959-10-3
- Min.Order: 0
- Payment Terms:
- Product Details
Keywords
- 7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 7-[5-[(aminosulfonyl)amino]-5-deoxy-beta-D-ribofuranosyl]-5-[2-(2-ethoxy-6-fluorophenyl)ethynyl]-
Quick Details
- ProName: TAS4464
- CasNo: 1848959-10-3
- Molecular Formula: C21H23FN6O6S
- Application: For research use only.
- PackAge: 5 mg
- Purity: 95%
- LimitNum: 0
Superiority
We provide customized and high-quality TAS4464 product for your project.
Details
TAS4464 is a potent and selective NEDD8 activating enzyme (NAE) inhibitor with IC50 of 0.955 nM. It selectively inhibits NAE relative to the other E1s UAE and SAE. TAS4464 treatment inhibits cullin neddylation and subsequently induces the accumulation of CRL substrates such as CDT1, p27, and phosphorylated IkBa in human cancer cell lines.
