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YM-53601 CAS NO.182959-33-7
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Keywords
- 9H-Carbazole, 2-[(2E)-2-(1-azabicyclo[2.2.2]oct-3-ylidene)-2-fluoroethoxy]-, hydrochloride (1:1)
- (E)-3-[2-(Carbazol-2-yloxy)-1-fluoroethylidene]quinuclidine hydrochloride
Quick Details
- ProName: YM-53601
- CasNo: 182959-33-7
- Molecular Formula: C21H21FN2O.HCl
- Appearance: Crystalline Solid
- Application: For research use only.
- Purity: ≥98%
- Storage: Store at -20°C
- LimitNum: 0
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Details
YM-53601 is a squalene synthase inhibitor with IC50s of 79 and 90 nM in HepG2 cells and rat liver microsomes, respectively. It is a lipid lowering agent that can reduce plasma cholesterol and triglyceride levels in vivo and inhibit cholesterol biosynthesis in rats (ED50 = 32 mg/kg). It is also an inhibitor of farnesyl-diphosphate farnesyltransferase 1 (FDFT1) enzyme activity and can inhibit the proliferation of HCV.
