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SHP099 CAS NO.1801747-42-1
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Keywords
- 6-(4-amino-4-methylpiperidin-1-yl)-3-(2,3-dichlorophenyl)pyrazin-2-amine
- SHP099
Quick Details
- ProName: SHP099
- CasNo: 1801747-42-1
- Molecular Formula: C16H19Cl2N5
- Appearance: Solid powder
- Application: For research use only.
- PackAge: 20 mg
- Purity: 95%
- Storage: Store in a cool and dry place (or refe...
- LimitNum: 0
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Details
SHP099 is a potent, selective, orally bioavailable, and efficacious SHP2 inhibitor (IC50 value 0.071 μM) that stabilizes SHP2 in an auto-inhibited conformation. SHP099 suppresses signaling through the Ras-ERK pathway and blocks the proliferation of receptor tyrosine kinase-driven human cancer cells in vitro and in vivo.
