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CBHA CAS NO.174664-65-4
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Keywords
- Histone Deacetylase Inhibitor II
- m-Carboxycinnamic acid bis-hydroxamide
Quick Details
- ProName: CBHA
- CasNo: 174664-65-4
- Molecular Formula: C10H10N2O4
- Appearance: Off-white Solid
- Application: Histone Deacetylase Inhibitors
- Purity: ≥98%
- LimitNum: 0
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Details
Histone deacetylase (HDAC) inhibitors hyperacetylate histones and increase transcriptional activity in selected genes. CBHA is a cell-permeable second generation hybrid polar agent that acts as a HDAC inhibitor. It exhibits ID50 values of 0.01 and 0.07 μM in vitro for HDAC1 and HDAC3, respectively. CBHA also induces apoptosis in nine different neuroblastoma cell lines in culture.
