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bpV(phen) potassium hydrate CAS NO.171202-16-7
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Keywords
- Bisperoxovanadium(phen)
- Potassium Bisperoxo(1,10-phenanthroline) oxovanadate (V)
Quick Details
- ProName: bpV(phen) potassium hydrate
- CasNo: 171202-16-7
- Molecular Formula: C12H8N2O5V·K+(H2O)3
- Appearance: Crystalline Solid
- Application: For research use only.
- Purity: ≥98%
- LimitNum: 0
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Details
BpV(phen) is a bisperoxovanadium (bpV) compound which inhibits several different protein tyrosine phosphatases (PTPs) with IC50 of 38 nM. It also inhibits the vascular endothelial PTP-β with IC50 of 343 nM and PTP-1β with IC50 of 920 nM. At 0.1 mM, bpV(phen) inhibits SH2 domain-containing inositol 5'-phosphatase-2. Presumably by inhibiting insulin receptor kinase-associated PTPs, bpV(phen) activates the insulin receptor tyrosine kinase and promotes downstream signaling, including activation of PI3-kinase.
