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Cathepsin L Inhibitor CAS NO.167498-29-5
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Keywords
- Z-FY-CHO
- Z-Phe-Tyr-aldehyde
Quick Details
- ProName: Cathepsin L Inhibitor
- CasNo: 167498-29-5
- Molecular Formula: C26H26N2O5
- Appearance: Crystalline Solid
- Application: For research use only.
- Purity: ≥95%
- Storage: Store at -20°C
- LimitNum: 0
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Details
Cathepsin L inhibitor is a potent inhibitor of cathepsin L with IC50 of 0.85 nM. It is trypanocidal with an ED50 value of 45 nM against T. brucei that is well below the ED50 value of 21,500 nM for human HL-60 cells. In vivo, cathepsin L inhibitor (2.5-10 mg/kg) inhibits bone loss in a mouse model of osteoporosis in a dose-dependent manner. Cathepsin L inhibitor can also completely suppress osteoclastic pit formation on femur slices isolated from bovine cortical bone.
