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BAR-501 CAS NO.1632118-69-4
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- Product Details
Keywords
- 3R,5S,6S,7S,8S,9S,10S,13R,14S,17R)-6-ethyl-17-((R)-5-hydroxypentan-2-yl)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthrene-3,7-diol
- BAR-501
Quick Details
- ProName: BAR-501
- CasNo: 1632118-69-4
- Molecular Formula: C26H46O3
- Appearance: Solid powder
- Application: For research use only.
- PackAge: 10 mg
- Purity: 95%
- Storage: Store in a cool and dry place and at 0...
- LimitNum: 0
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Details
BAR-501, a UDCA derivative, is a selective GPBAR1 agonist devoid of any FXR agonistic activity. BAR-501 effectively transactivates GPBAR1 in HEK293 cells overexpressing a CRE along with GPBAR1, with a EC50 of 1 μM. Besides, it protects against development of portal hypertension in rodent models of liver injury and endothelial dysfunction.
