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Home > Products >  DL-Pyroglutamic acid

DL-Pyroglutamic acid CAS NO.149-87-1

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Keywords

  • 5-oxoproline
  • DL-2-Pyrrolidone-5-carboxylic acid

Quick Details

  • ProName: DL-Pyroglutamic acid
  • CasNo: 149-87-1
  • Molecular Formula: C5H7NO3
  • Appearance: White Crystalline Powder
  • Application: For research use only.
  • Purity: ≧ 95%
  • Storage: Store at 2-8 °C
  • LimitNum: 0

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Details

Pyroglutamic acid (also known as PCA, 5-oxoproline, pidolic acid, or pyroglutamate for its basic form) is an uncommon and little studied amino acid derivative in which the free amino group of glutamic acid or glutamine cyclizes to form a lactam. It is a metabolite in the glutathione cycle that is converted to glutamate by 5-oxoprolinase. Pyroglutamate is found in many proteins including bacteriorhodopsin. N-terminal glutamic acid and glutamine residues can spontaneously cyclize to become pyroglutamate. This is one of several forms of blocked N-terminals which present a problem for N-terminal sequencing using Edman chemistry, which requires a free primary amino group not present in pyroglutamic acid. The enzyme pyroglutamate aminopeptidase can restore a free N-terminus by cleaving off the pyroglutamate residue.

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