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Abacavir EP Impurity B CAS NO.1443421-69-9
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Keywords
- N6-Cyclopropyl-9-((1R,4S)-4-(((2,5-diamino-6-chloropyrimidin-4-yl)oxy)methyl)cyclopent-2-en-1-yl)-9H-purine-2,6-diamine
- Abacavir 5'-4-Chloro-6-methylpyrimidine-2,5-diamine
Quick Details
- ProName: Abacavir EP Impurity B
- CasNo: 1443421-69-9
- Molecular Formula: C18H21ClN10O
- Application: For research use only.
- Purity: 95%
- LimitNum: 0
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Details
Abacavir 5'-4-Chloro-6-methylpyrimidine-2,5-diamine (Abacavir EP Impurity B) is a degradation product of Abacavir Sulfate. Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection. Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA. Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
