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Cl-Amidine hydrochloride CAS NO.1373232-26-8
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Keywords
- N-[(1S)-1-(aminocarbonyl)-4-[(2-chloro-1-iminoethyl)amino]butyl]-benzamide monohydrochloride
Quick Details
- ProName: Cl-Amidine hydrochloride
- CasNo: 1373232-26-8
- Molecular Formula: C14H19ClN4O2·HCl
- Appearance: Crystalline Solid
- Application: For research use only.
- Purity: ≥95%
- LimitNum: 0
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Details
Cl-amidine is an inhibitor of irreversible protein pan-peptidylarginine deiminase (PAD) with IC50 values of 5.9 ± 0.3 μM, 0.8 ± 0.3 μM, 6.2 ± 1.0 μM for PAD4, PAD1 and PAD3, respectively. It irreversibly inactivates all four PAD subtypes by covalently modifying an active site cysteine that is important for its catalytic activity.
