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ent-Abacavir CAS NO.136470-79-6
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Keywords
- (1R,4S)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol
- (1R-cis)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol
Quick Details
- ProName: ent-Abacavir
- CasNo: 136470-79-6
- Molecular Formula: C14H18N6O
- Appearance: Off-White to Pale Yellow Solid
- Application: Anti-HIV Agents
- Purity: 97%
- Storage: Store at -20°C
- LimitNum: 0
Superiority
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Details
ent-Abacavir (Abacavir EP Impurity A) is an enantiomer of Abacavir. Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection. Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA. Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
