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Hepcidin-25 (human) CAS NO.1356390-47-0
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Keywords
- LEAP-1 (human)
- H-Asp-Thr-His-Phe-Pro-Ile-Cys-Ile-Phe-Cys-Cys-Gly-Cys-Cys-His-Arg-Ser-Lys-Cys-Gly-Met-Cys-Cys-Lys-Thr-OH (Disulfide bridge: Cys7-Cys23, Cys10-Cys13, Cys11-Cys19, Cys14-Cys22)
Quick Details
- ProName: Hepcidin-25 (human)
- CasNo: 1356390-47-0
- Molecular Formula: C113H170N34O31S9
- Appearance: White Powder
- Application: Anti-Infective Agents
- Purity: ≥95% by HPLC
- Storage: Store at -20°C
- LimitNum: 0
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Details
Hepcidin-25 (hepatic bactericidal protein), also known as LEAP-1 (liver-expressed antimicrobial peptide), is found independently in human blood ultrafiltration and urine. It is mainly expressed in liver and belongs to a new family of small vertebrate antimicrobial peptides that contain 8 cysteine residues and has obvious antibacterial and antifungal activities. Hepcidin is the main human iron regulatory hormone, which can bind to iron exporter ferroportin and induce its internalization and degradation, thus blocking iron efflux from cells.
