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PACAP-38 (human, mouse, ovine, porcine, rat) CAS NO.124123-15-5
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Keywords
- Pituitary Adenylate Cyclase Activating Polypeptide-38 (human, mouse, ovine, porcine, rat)
- H-His-Ser-Asp-Gly-Ile-Phe-Thr-Asp-Ser-Tyr-Ser-Arg-Tyr-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Ala-Ala-Val-Leu-Gly-Lys-Arg-Tyr-Lys-Gln-Arg-Val-Lys-Asn-Lys-NH2
Quick Details
- ProName: PACAP-38 (human, mouse, ovine, porcine...
- CasNo: 124123-15-5
- Molecular Formula: C203H331N63O53S
- Appearance: White or Off-white Lyophilized Powder
- Application: For research use only.
- Purity: 95%
- Storage: Store at -20°C
- LimitNum: 0
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PACAP-38 (human, mouse, ovine, porcine, rat) is a multifunctional neuropeptide that interacts with PACAP receptors and vasoactive intestinal peptide receptors to enhance intracellular cyclic AMP levels and exert systemic effects. It is a PAC1 agonist that strongly increases α-secretase activity. Upregulation of the APP-degrading enzyme promotes non-amyloidogenic processing of APP by reducing Aβ40/42 production, and thus may contribute to the prevention of Alzheimer's disease. Intranasal application of PACAP-38 in APP[V717I]-transgenic mice promotes the production of Aβ-degrading enzyme neprilysin by inducing somatostatin.
