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Home > Products >  Oclacitinib

Oclacitinib CAS NO.1208319-26-9

  • Min.Order: 1 Gram
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  • Product Details

Keywords

  • PF-03394197
  • JAKI
  • cas 1208319-26-9

Quick Details

  • ProName: Oclacitinib
  • CasNo: 1208319-26-9
  • Molecular Formula: C15H23N5O2S
  • Application: inhibitor
  • DeliveryTime: 7 days
  • ProductionCapacity: 1 Kilogram/Month
  • Purity: 98%
  • LimitNum: 1 Gram

Superiority

BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds. #

Details

Oclacitinib, also known as PF03394197, is a novel Janus kinase inhibitor with activity against cytokines involved in allergy. Oclacitinib inhibited JAK family members by 50% at concentrations (IC50 's) ranging from 10 to 99 nM and did not inhibit a panel of 38 non-JAK kinases (IC50 's > 1000 nm). Oclacitinib was most potent at inhibiting JAK1 (IC50 = 10 nm). Oclacitinib also inhibited the function of JAK1-dependent cytokines involved in allergy and inflammation (IL-2, IL-4, IL-6, and IL-13) as well as pruritus (IL-31) at IC50 's ranging from 36 to 249 nm. Oclacitinib had minimal effects on cytokines that did not activate the JAK1 enzyme in cells (erythropoietin, granulocyte/macrophage colony-stimulating factor, IL-12, IL-23; IC50 's > 1000 nm). These results demonstrate that oclacitinib is a targeted therapy that selectively inhibits JAK1-dependent cytokines involved in allergy, inflammation, and pruritus and suggests these are the mechanisms by which oclacitinib effectively controls clinical signs associated with allergic skin disease in dogs.

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