WT-161 CAS NO.1206731-57-8

We provide customized and high-quality WT-161 product for your project.

WT-161 is a potent and specific HDAC6 inhibitor (IC50 = 0.40 nM). Consistent with WT-161 mediated hyperacetylation and inhibition of hsp90 chaperone function, treatment with WT-161 increased the intracellular levels of polyubiuitylated proteins in the cultured MCL JeKo-1 and Z138 cells. WT-161 was also noted to dose-dependently deplete the levels of cyclin D1 in the cultured MCL cells.