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Epacadostat CAS NO.1204669-58-8
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- Product Details
Keywords
- IDO inhibitor 1
- 1,2,5-Oxadiazole-3-carboximidamide, 4-[[2-[(aminosulfonyl)amino]ethyl]amino]-N-(3-bromo-4-fluorophenyl)-N'-hydroxy-, [C(Z)]-
Quick Details
- ProName: Epacadostat
- CasNo: 1204669-58-8
- Molecular Formula: C11H13BrFN7O4S
- Appearance: White to off-white solid powder
- Application: For research use only.
- PackAge: 100 mg
- Purity: ≥95%
- Storage: Store at -20°C
- LimitNum: 0
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Details
Epacadostat, also known as INCB024360 or INCB24360, is a potent and selective IDO1 inhibitor with IC50 of 71.8 nM±17.5 nM, with potential immunomodulating and antineoplastic activities. It has been shown to promote T and natural killer-cell growth, to increase IFN-γ production, and to reduce conversion to regulatory T (Treg)-like cells in a coculture system of human allogeneic lymphocytes with either dendritic cells or tumor cells.
