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LY2811376 CAS NO.1194044-20-6
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Keywords
- 4H-1,3-Thiazin-2-amine, 4-[2,4-difluoro-5-(5-pyrimidinyl)phenyl]-5,6-dihydro-4-methyl-, (4S)-
- (4S)-4-[2,4-Difluoro-5-(5-pyrimidinyl)phenyl]-5,6-dihydro-4-methyl-4H-1,3-thiazin-2-amine
Quick Details
- ProName: LY2811376
- CasNo: 1194044-20-6
- Molecular Formula: C15H14F2N4S
- Appearance: Crystalline Solid
- Application: For research use only.
- Purity: ≥95%
- Storage: Store in a cool and dry place and at 2...
- LimitNum: 0
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Details
LY2811376, under the IUPAC name (4S)-4-(2,4-difluoro-5-pyrimidin-5-ylphenyl)-4-methyl-5,6-dihydro-1,3-thiazin-2-amine, is the first orally available non-peptidi Beta secretase (BACE) inhibitor (IC50 = 239-249 nM) with the potent effect of treating Alzheimer's Disease. In vivo, LY2811376 inhibits BACE1 activity by concomitantly reducing C99 and sAPPb, the two primary APP cleavage products generated by BACE1. In vitro, LY2811376 demonstrates concentration-dependent inhibition of hBACE1 with an IC50 of 239 and 249 nM.
