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Antagonist G CAS NO.115150-59-9
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Keywords
- [Arg6,D-Trp7,9,N-MePhe8]-Substance P(6-11)
Quick Details
- ProName: Antagonist G
- CasNo: 115150-59-9
- Molecular Formula: C49H66N12O6S
- Application: For research use only.
- PackAge: 1 mg
- Purity: 98%
- Storage: Store at -20°C
- LimitNum: 0
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Details
Antagonist G is a substance P analog, which is a broad spectrum neuropeptide growth factor antagonist and antiproliferative agent. It was developed for the treatment of small cell lung cancer. It could inhibit neuropeptide-dependent and -independent proliferation of small cell lung cancer in vitro. It also inhibits growth of SCLC xenografts in mice in vivo. It blocks Swiss 3T3 cell growth induced by vasopressin, gastrin-releasing peptide and bradykinin. It activates JNK and stimulates apoptosis. It is an anticancer agent and is resistant to degradation by peptidases.
