United States
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- Product Details
Keywords
- Pam3-Cys-Ser-Lys-Lys-Lys-Lys
- (S)-[2,3-Bis(palmitoyloxy)-(2-RS)-propyl]-N-palmitoyl-(R)-Cys-(S)-Ser-(S)-Lys4-OH
Quick Details
- ProName: Pam3CSK4
- CasNo: 112208-00-1
- Molecular Formula: C81H156N10O13S
- Appearance: Lyophilized powder
- Application: For research use only.
- DeliveryTime: 7 days
- PackAge: 5 mg
- ProductionCapacity: 1 Kilogram/Month
- Purity: ≥95%
- Storage: Store at 2-8°C
- LimitNum: 1 Gram
Superiority
We provide customized and high-quality Pam3CSK4 product for your project.
Details
Pam3CSK4 is a TLR 1/2 agonist and a cell-permeable, water-soluble synthetic tripalmitoylated lipopeptide that mimics the acylated amino terminus of bacterial LPs. Bacterial LPs are a family of pro-inflammatory cell wall components found in both Gram-positive and Gram-negative bacteria. Pam3CSK4 is a potent activator of the pro-inflammatory transcription factor NF-κB. It induces production of TNF-α, superoxide, NO, and IL-6, stimulates phosphorylation of p100/p110 and p60 in granulocytic-differentiated HL-60 cells, promotes differentiation of naive CD4+ T cells into Th17 cells, and enhances tyrosine protein phosphorylation and activation of ERK1/2 and MEK1/2. It is used in prevention of inflammation caused by certain bacterial infection.
