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Home > Products >  Atazanavir-[d6]

Atazanavir-[d6] CAS NO.1092540-50-5

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Keywords

  • Atazanavir D6
  • (3S,8S,9S,12S)-12-Bis(1,1-dimethylethyl)-8-hydroxy-4,11-dioxo-9-(phenylmethyl)-6-[[4-(2-pyridinyl)phenyl]methyl]-2,5,6,10,13-Pentaazatetradecanedioic Acid 14-di(methyl-d3) Ester

Quick Details

  • ProName: Atazanavir-[d6]
  • CasNo: 1092540-50-5
  • Molecular Formula: C38H46D6N6O7
  • Appearance: Solid powder
  • Application: For research use only.
  • Purity: ≥98%; ≥99% atom D
  • Storage: Store at -20°C
  • LimitNum: 0

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Details

Atazanavir-[d6] is the labelled analogue of Atazanavir. Atazanavir is a novel and potent azapeptide protease inhibitor that specifically inhibits the human immunodeficiency virus type 1 (HIV-1) protease enzyme with inhibition constant Ki of 66 nmol/L and also inhibits the viral replication of HIV-1 with 50% effective concentration EC50 ranging from 2.6 to 5.3 nmol/L. Atazanavir binds to HIV-1 protease preventing the cleavage of gag and gag-pol polyproteins, which results in the formation of immature virions in HIV-1-infected cells. Atazanavir has a different C-2 symmetric chemical structure and a generally greater antiretroviral potency in various HIV strains compared to other protease inhibitors, including indinavir, nelfinavir, ritonavir, saquinavir and amprenavir.

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