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Topotecan-[d6] Hydrochloride CAS NO.1044746-98-6
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Keywords
- (4S)-10-[[Di(methyl-d3)amino]methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione Hydrochloride (1:1)
Quick Details
- ProName: Topotecan-[d6] Hydrochloride
- CasNo: 1044746-98-6
- Molecular Formula: C23H18D6ClN3O5
- Application: For research use only.
- Purity: 95%
- LimitNum: 0
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Details
Labelled Topotecan Hydrochloride. Topocecan is a semisynthetic derivative of camptothecin with antineoplastic activity. During the S phase of the cell cycle, topotecan selectively stabilizes topoisomerase I-DNA covalent complexes, inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when complexes are encountered by the DNA replication machinery. Camptothecin is a cytotoxic quinoline-based alkaloid extracted from the Asian tree Camptotheca acuminata.
