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Ceritinib CAS NO.1032900-25-6
- Min.Order: 1 Gram
- Payment Terms: L/C
- Product Details
Keywords
- Ceritinib
- 1032900-25-6
- 5-Chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine， LDK378,Zykadia,1380575-43-8 (2HCl), 1190399-48-4 (xHCl)
Quick Details
- ProName: Ceritinib
- CasNo: 1032900-25-6
- Molecular Formula: C28H36ClN5O3S
- Appearance: Solid Powder
- Application: research use
- DeliveryTime: 7 days
- PackAge: inquiry
- Port: inquiry
- ProductionCapacity: 10 Kilogram/Month
- Purity: 98%
- Transportation: inquiry
- LimitNum: 1 Gram
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Details
An anaplastic lymphoma kinase (ALK)-positive inhibitor used for the treatment of non-small cell lung cancer (NSCLC). It less potently inhibits IGF-1R, InsR, and STK22D and IC50 value is 8, 7, and 23 nM. LDK378 is also minimally effective against a panel of other kinases. In Sep 2016, Interim adverse events and efficacy data from phase III ASCEND-4 trial in non small cell lung cancer released by Novartis. In Oct 2016, efficacy data from the phase III ASCEND-3 and ASCEND-5 trial in non small cell lung cancer was presented.