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PR-104 CAS NO.851627-62-8
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Keywords
- PR 104
- PR104
Quick Details
- ProName: PR-104
- CasNo: 851627-62-8
- Molecular Formula: C14H20BrN4O12PS
- Appearance: Solid Powder
- Application: For research use only.
- Purity: ≥97%
- Storage: Store at -80°C, stored under nitrogen,...
- LimitNum: 0
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Details
PR-104 is a non-toxic, small-molecule, hypoxia-activated, 3,5-dinitrobenzamide nitrogen mustard pre-prodrug with potential antitumor activity. Upon intravenous administration, PR-104 is converted by systemic phosphatases to the alcohol intermediate PR-104A, which is reduced to form the active DNA-crosslinking mustard species hydroxylamine PR-104H intracellularly under hypoxic conditions. PR-104H specifically crosslinks hypoxic tumor cell DNA, resulting in the inhibition of DNA repair and synthesis, cell-cycle arrest, and apoptosis in susceptible hypoxic tumor cell populations while sparing normoxic tissues.
