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A 410099.1 CAS NO.762274-58-8
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Keywords
- N-Methyl-L-alanyl-(2S)-2-cyclohexylglycyl-N-[(1R)-1,2,3,4-tetrahydro-1-naphthalenyl]-L-prolinamide hydrochloride
Quick Details
- ProName: A 410099.1
- CasNo: 762274-58-8
- Molecular Formula: C27H40N4O3·HCl
- Appearance: Solid Powder
- Application: For research use only.
- Purity: ≥98%
- LimitNum: 0
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Details
A 410099.1 is a high affinity XIAP antagonist (Kd = 16 nM for the BIR3 domain of XIAP). Exhibits cytotoxicity in a wide range of cancer cell lines in vitro (EC50 = 13 nM in MDA-MB-231 cells). Also displays antitumor activity in a mouse breast cancer xenograft model. Enhances TRAIL-induced apoptosis in chronic lymphocytic leukemia (CLL) cells.
