Cafestol CAS NO.469-83-0

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Cafestol is a natural bioactive substance isolated from the unsaponifiable fraction of petroleum ether extract of coffee beans, it acts as a GST (glutathione S-transferase) inducer and exhibits chemoprotective activity. Dietary cafestol does increase total cholesterol and triglycerides in ApoE3Leiden mice, an effect which is associated with selective activation of farnesoid X receptors and pregnane X receptors.