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CCF-642 CAS NO.346640-08-2
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Keywords
- 3-(4-Methoxyphenyl)-5-[(5-nitro-2-thienyl)methylene]-2-thioxo-4-thiazolidinone
- CCF-642
Quick Details
- ProName: CCF-642
- CasNo: 346640-08-2
- Molecular Formula: C15H10N2O4S3
- Appearance: Brown solid powder
- Application: For research use only.
- Purity: 95%
- Storage: Store in a cool and dry place (or refe...
- LimitNum: 0
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Details
CCF-642 is a protein disulfide isomerase (PDI) inhibitor that exhibits 100-fold higher potency than PACMA 31 (by di-E-GSSG assay) via an alternative mode of action. CCF642 displayed potent efficacy in an aggressive syngeneic mouse model of multiple myeloma and prolonged the lifespan of C57BL/KaLwRij mice engrafted with 5TGM1-luc myeloma, an effect comparable to the first-line multiple myeloma therapeutic bortezomib.
