AZ31 CAS NO.2088113-98-6

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AZ31 is a potent and highly selective ATM inhibitor with an IC50 of <1.2 nM. It displays excellent selectivity against a panel of kinases including ATR, DNAPK, mTOR, PI3Kα, PI3Kβ, PI3Kγ, GSK3β and KDR. AZ 31 also shows significant tumor growth reduction in the SW620 xenograft model combined with irinotecan.