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Parecoxib Impurity 24 CAS NO.198470-82-5
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Keywords
- N-((4-(5-Methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)isobutyramide
- 2-methyl-N-[4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)phenyl]sulfonylpropanamide
Quick Details
- ProName: Parecoxib Impurity 24
- CasNo: 198470-82-5
- Molecular Formula: C20H20N2O4S
- Appearance: Solid
- Application: For research use only.
- PackAge: 5 mg
- Purity: 95%
- Storage: -20°C
- LimitNum: 0
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Details
An impurity of Parecoxib. The prodrug Parecoxib as well as its active metabolite val have a specific affinity to the cannabinoid (CB) receptor measured in CB1-expressing HEK 293 cells and rat brain tissue. Adult male Sprague-Dawley rats were administered parecoxib (10 or 30 mg kg(-1), IP) or isotonic saline twice a day starting 24 h after middle cerebral artery occlusion (MCAO) for three consecutive days. The selective COX-2 inhibitor parecoxib was delivered 20 min before or 20 min after the incision by intraperitoneal injection. Pretreatment with parecoxib markedly attenuated the pain hypersensitivity induced by incision.
