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EAI045 CAS NO.1942114-09-1
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Keywords
- 2-(5-fluoro-2-hydroxyphenyl)-2-(3-oxo-1H-isoindol-2-yl)-N-(1,3-thiazol-2-yl)acetamide
- 2-(5-fluoro-2-hydroxyphenyl)-2-(1-oxo-2,3-dihydro-1H-isoindol-2-yl)-N-(1,3-thiazol-2-yl)acetamide
Quick Details
- ProName: EAI045
- CasNo: 1942114-09-1
- Molecular Formula: C19H14FN3O3S
- Appearance: Solid powder
- Application: For research use only.
- PackAge: 50 mg
- Purity: 95%
- Storage: Store in a cool and dry place and at 0...
- LimitNum: 0
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Details
EAI045 is an allosteric, non-ATP competitive inhibitor of mutant EGFR. In vitro studies proved that EAI045 is active and selective for T790M- harboring EGFR mutants that are in a monomer state. In vivo the combination of EAI045 and cetuximab caused a marked tumor shrinkage in a mouse model carrying the EGFR mutant with L858R/T790M/C797S. Therefore, EAI045 is the first allosteric inhibitor that targets T790M and C797S EGFR mutants but it is effective only in combination with cetuximab.
