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Plevitrexed CAS NO.153537-73-6
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Keywords
- ZD 9331
- BGC9331
Quick Details
- ProName: Plevitrexed
- CasNo: 153537-73-6
- Molecular Formula: C26H25FN8O4
- Appearance: Solid Powder
- Application: Antineoplastic Agents
- Purity: ≥95%
- Storage: Store at 2-8°C for short term (days to...
- LimitNum: 0
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Plevitrexed is an orally bioavailable, small molecule, non-polyglutamatable, antifolate quinazoline derivative thymidine synthetase inhibitor with potential antineoplastic activity. Plevitrexed is transported into the cell via the physiological reduced folate carrier (RFC) system. Intracellularly, this agent selectively binds to the folate binding site of thymidylate synthase and inhibits thymidine synthesis, which may result in DNA synthesis inhibition and apoptosis.
