C3bot (154-182) CAS NO.1246280-79-4

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C3bot (154-182) is a transferase-deficient neurotrophic fragment of clostridial C3 protein. It promotes axonal and dendritic growth and branching of hippocampal neurons at submicromolar concentrations and promotes reinnervation of target tissues in organotypical hippocampal/entorhinal slice cultures. It reduces levels of active neuronal RhoA by a non-enzymatic mechanism and enhances functional recovery and regeneration in a mouse model of spinal cord injury.